E Ink based digital note taking devices have WACOM pens with the capability of only 4,096 degrees of pressure sensitivity. If you need a bigger screen and 8,192 levels of pressure sensitivity then you might want to take a look at the new Cintiq that has a giant 22 inch screen.
The Cintiq 22 is a follow up from the Cintiq 16 that came out earlier this year and cost a respectable $649. This new device has a massive 21.5-inch screen with a 1920 x 1080 resolution, 72% NTSC color, and an anti-glare glass surface that has a paper-like feel to draw on. It has a USB 2.0 port and HDMI to plug into your computer and this product works really well with Adobe Photoshop and Illustrator. It comes with an adjustable stand and is retailing for $1,100 on Amazon.
The Cintiq line is geared towards students and people who have never had a device like this before. The PRO line is really where Wacom shines, but they are expensive and more geared towards enterprise. They have 4K screens, more accurate colors, and better optical bonding, which reduces parallax, or the distance between the pen and the screen.
When I was doing technical art at various game studios in a past life, all of the artists at WACOM pads just like this, they were basically used for character and environmental art. The latency was really low, which was useful for coloring and shading.
Michael Kozlowski is the Editor in Chief of Good e-Reader. He has been writing about audiobooks and e-readers for the past ten years. His articles have been picked up by major and local news sources and websites such as the CBC, CNET, Engadget, Huffington Post and the New York Times.